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Right patient. Right drug. Right dose. Right genome. Why genetic diversity is vital for pharmacogenomics May 30, 2019 Drug development is an expensive business. Not only may it cost hundreds of millions of dollars to successfully bring a drug from concept to market, but the reality is that up to 90 per cent of drugs fail in the early stages of clinical trials. Even if a medicine does reach the point of sale, it probably won’t be effective in all patients with the same condition. If we are to provide people ...
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Why we must work to increase diversity in genomic datasets May 23, 2019 The release of the first draft Human Genome sequence in 2001 was rightly hailed as a momentous occasion in human history. Doctors and scientists gazed into an exciting future promising new, better ways of diagnosing, preventing and treating disease based on each patient’s genetic makeup - even if the precise technology was yet to be developed. Over the past couple of decades, doctors and pha...
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One among many – why there’s no such thing as ‘The Human Genome’ March 13, 2019 Over the past couple of decades we’ve grown used to the idea of the Human Genome – the genetic blueprint that all of us carry within our cells, containing all the instructions for life. The information within our DNA constructs all the parts of the body as we grow from a single fertilised egg into a baby and then an adult. Our genome also tells us something (but not everything) about all...
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Skip to the good bit: how ‘leapfrog’ technology will revolutionise global healthcare March 1, 2019 In our modern, connected world it’s easy to take the technology that surrounds us for granted. Structures like mobile phone masts, telephone junction boxes and power lines are so ubiquitous that we barely notice them, yet behind these everyday objects lie centuries of iteration and optimisation. In places like the US and Europe, engineers and innovators have built layers upon layers of techn...
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Gathering genetic insights in India brings opportunities for precision medicine February 12, 2019 India is a land of growth and industry, with the world’s sixth-largest economy… and 1.3 billion human genomes. But although the subcontinent comprises around 20% of the world's population, the DNA sequences of its people currently make up less than 1% of global genetic databases. In 2009, a mere 4% of data in genomic databases originated from people with non-European ancestry. That fi...
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In it to win it – addressing the lack of global genomic data diversity January 24, 2019 The issue of increasing diversity in genomic data is gathering ever more attention. It was a hot topic for discussion at the recent Festival of Genomics in London, UK, from the opening keynote lecture by Professor Mark Caulfield,  chief scientist of Genomics England to discussion sessions during the event. Earlier this month, a review of genome-wide association studies (GWAS) came out fr...
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From human genome to global genome – why diversity matters for precision medicine January 19, 2019 The release of the first draft sequence of the Human Genome in 2001 was an historic milestone for mankind. For scientists and physicians, this event marked the start of the genetic revolution – we would finally understand the underlying causes of a wide range of conditions, from diabetes and heart disease to cancers and rare genetic syndromes. Armed with this knowledge, it would be possi...
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Democratising healthcare through genomics – the story behind Global Gene Corp’s mission January 8, 2019 Global Gene Corp’s CEO, Sumit Jamuar, shares the vision that underpins what we’re doing to bring the benefits of genomics and personalised medicine to everyone, wherever they are. Watch his talk from TEDx Roma to hear his story. I have fond memories of growing up in India and the rural holidays I took with my brother Saumya. We would make the 1000 kilometre railway journey from India’s c...